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Spectrum proudly offers proprietary KrosFlo hollow fiber membranes for implant technology to provide a
TRUE-to-LIFE response for drug screening and cancer research. Perfectly suited for implantation, the modified
Polyvinylidene Difluoride (mPVDF) hollow fiber membrane is biocompatible, resistant to cell adhesion, hydrophobic
and resistant to a wide variety of organic solvents, including most aqueous acids and bases. Furthermore, these hollow
fibers can be heat sealed and autoclaved without affecting the molecular weight cut off (500,000 Dalton MWCO) or
changing the membrane performance.
TRUE-to-LIFE! The KrosFlo Implant Membranes has been shown to be biocompatible in various animal models for periods exceeding 14 days.
Multiple cell lines have been grown both in vitro and in vivo
within the KrosFlo Implant Membranes. Cell lines grown within KrosFlo
Implant Membranes, which have been implanted into a host animal, are not subject to immunological attack by
the host animal. KrosFlo Implant Membranes containing cancer cell lines have been implanted into mice and used
to screen for compounds having anti cancer activity. Similarly, KrosFlo Implant Membranes containing HIV infected cell
lines have been implanted into mice and used to screen for compounds having anti-HIV activity. Literature describing the
implantation of KrosFlo Implant Membrane in these animal models is available at www.spectrumlabs.com.
Encapsulated cells can be:
- Established cancer cell lines
- Virus infected cells
- Hematopoietic cells
- Bacteria
- Fungi
KrosFlo Implant Membranes isolate:
- Immune systems cells
- Viruses
- Mycoplasma
KrosFlo Implant Membranes have:
- Biocompatible inner and outer surface
Advantages over current xenographic model:
- 10 day assay versus 60 day assay
- Smaller assay variability, fewer animals needed
- Uses lesser amounts of test compounds
- Multiple cell lines can be tested simultaneously in same animal
- Compatible with different cell lines
| Packaging: | Wet in DI water and autoclaved or Dry and not autoclaved |
| Material: | PVDF |
| Inner Diameter: | 1.0 mm |
| Outer Diameter: | 1.2 mm |
| Length: | 34 cm per fiber |
| Quantity: | Three fibers per package |
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| Click on any part number for pricing information or to place an order.  
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